Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit


  • This work was supported by the NEXT Program and partly by Grant-in-Aid number 22685018 from JSPS. We thank Mr. T. Abe of Oxford Instruments for helpful discussion and technical assistance on the DNP experiments.


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How to live longer: A fully deuterated 13C methoxy group (13CD3O) is presented as a new long-lived hyperpolarization unit for designing a sensitive 13C magnetic resonance probe. By utilizing the unit, a hyperpolarized magnetic resonance probe for sensing hypochlorous acid was successfully designed.