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Keywords:

  • aptamers;
  • biosensors;
  • current amplification;
  • electrochemistry;
  • paper fluidic devices
Thumbnail image of graphical abstract

Paper biosensors: An origami sensor is printed on a single piece of paper, folded into a three-dimensional fluidic device, and encapsulated by thermal lamination. Aptamer is trapped in the fluidic channel, where it binds to the target and releases an enzyme to generate a signal. The device is read out using a digital multimeter.