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Probing Bacterial-Toxin Inhibition with Synthetic Glycopolymers Prepared by Tandem Post-Polymerization Modification: Role of Linker Length and Carbohydrate Density

Authors


  • Equipment used in this research was funded in part through support from Advantage West Midlands (A.W.M.) Science City Initiative and funded in part by the ERDF. D.M.H. is a Wolfson/Royal Society Fellow and M.I.G. is a HEFCE Science City Senior Fellow. S.-J.R. acknowledges the EPSRC funded MOAC DTC for a studentship and M.W.J. acknowledges the EPSRC for a knowledge transfer secondment.

Abstract

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Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.

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