Near-Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics

Authors


  • This work was supported in part by the NIH (grant number R21EB009853 to J.Z.), CPRIT (grant numberRP120588 J.Z. and X.S.) and the start-up fund from the University of Texas at Dallas (J.Z.). The purchase of the NanoSPECT-CT scanner was partially supported by an NIH shared instrumentation grant (grant number 1S10RR029674-01 to O.K.Ö.).

Abstract

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A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

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