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Keywords:

  • aldol reaction;
  • cross-coupling;
  • polyene antibiotics;
  • protecting-group-free synthesis;
  • total synthesis
Thumbnail image of graphical abstract

The MIDA touch: A concise and highly convergent protecting-group-free total synthesis of (−)-myxalamide A involves a stereoselective vinylogous Mukaiyama aldol reaction of a vinylketene silyl N,O-acetal, together with a one-pot Stille/Suzuki–Miyaura cross-coupling reaction using Burke's N-methyliminodiacetic acid (MIDA) boronate to connect left- and right-hand fragments of the molecule (see scheme).