We thank the National Natural Science Foundation of China (21162040, 20902080) and RGC (PolyU 5010/11P), SKL for financial support.
Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts†
Article first published online: 28 JUN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 31, pages 7821–7824, July 27, 2012
How to Cite
Fan, B.-M., Yang, Q.-j., Hu, J., Fan, C.-l., Li, S.-f., Yu, L., Huang, C., Tsang, W. W. and Kwong, F. Y. (2012), Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts . Angew. Chem. Int. Ed., 51: 7821–7824. doi: 10.1002/anie.201203107
- Issue published online: 25 JUL 2012
- Article first published online: 28 JUN 2012
- Manuscript Received: 23 APR 2012
- National Natural Science Foundation of China. Grant Numbers: 21162040, 20902080
- asymmetric catalysis;
- CH activation;
- synthetic methods
Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod=1,5-cyclooctadiene, DCE=1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH2, OH, Br, F, and SiMe3 groups remain intact during the reaction.