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Keywords:

  • alcohol dehydrogenases;
  • alcohol oxidation;
  • aldehyde oxidation;
  • dynamic kinetic resolution;
  • profens
Thumbnail image of graphical abstract

Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.