Rhodium(III)-Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes


  • We thank Dr. Matthew Hopkinson and Dr. Honggen Wang for helpful discussions. This work was supported by the Alexander von Humboldt Foundation (Z.S.). Generous financial support by the DFG (IRTG Münster–Nagoya) and by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC grant agreement no. 25936 is gratefully acknowledged.


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Your CHOice! An efficient RhIII-catalyzed dehydrogenative Heck reaction (DHR) of salicylaldehydes with different classes of olefins extends the oxidative Heck reaction to aldehyde C[BOND]H bonds. Several structural motifs similar to natural products and bioactive molecules such as aurones, flavones, 2′-hydroxychalcones, and flavanones could be efficiently produced. Initial mechanistic studies give insight into the reaction mechanism.