We thank Dr. Matthew Hopkinson and Dr. Honggen Wang for helpful discussions. This work was supported by the Alexander von Humboldt Foundation (Z.S.). Generous financial support by the DFG (IRTG Münster–Nagoya) and by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC grant agreement no. 25936 is gratefully acknowledged.
Rhodium(III)-Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes†
Article first published online: 28 JUN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 32, pages 8092–8096, August 6, 2012
How to Cite
Shi, Z., Schröder, N. and Glorius, F. (2012), Rhodium(III)-Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes. Angew. Chem. Int. Ed., 51: 8092–8096. doi: 10.1002/anie.201203224
- Issue published online: 1 AUG 2012
- Article first published online: 28 JUN 2012
- Manuscript Received: 26 APR 2012
- Alexander von Humboldt Foundation
- European Research Council. Grant Number: 25936
- CH functionalization;
- dehydrogenative Heck reaction;
Your CHOice! An efficient RhIII-catalyzed dehydrogenative Heck reaction (DHR) of salicylaldehydes with different classes of olefins extends the oxidative Heck reaction to aldehyde CH bonds. Several structural motifs similar to natural products and bioactive molecules such as aurones, flavones, 2′-hydroxychalcones, and flavanones could be efficiently produced. Initial mechanistic studies give insight into the reaction mechanism.