These authors contributed equally to this work.
Inside Cover: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012)
Article first published online: 13 MAY 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 23, page 5508, June 4, 2012
How to Cite
Herzog, I. M., Green, K. D., Berkov-Zrihen, Y., Feldman, M., Vidavski, R. R., Eldar-Boock, A., Satchi-Fainaro, R., Eldar, A., Garneau-Tsodikova, S. and Fridman, M. (2012), Inside Cover: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012). Angew. Chem. Int. Ed., 51: 5508. doi: 10.1002/anie.201203240
- Issue published online: 30 MAY 2012
- Article first published online: 13 MAY 2012
- Cited By
- aminoglycoside-modifying enzymes;
Amphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication on page 5652 ff., M. Fridman, S. Garneau-Tsodikova, and co-workers report the synthesis of 6′′-thioether tobramycin derivatives and show that their aliphatic chain acts as a drill bit that can rupture bacterial cells. These potent compounds evade many of the common bacterial resistance mechanisms, thereby opening a new avenue for the discovery of membrane-targeting antibiotics.