The authors thank NIGMS (R01 GM084254) and UCSB for generous financial support, and Sigma–Aldrich for generous donation of BrettPhosAuNTf2.
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Communication
Access to Electron-Rich Arene-Fused Hexahydroquinolizinones through a Gold-Catalysis-Initiated Cascade Process†
Article first published online: 12 JUN 2012
DOI: 10.1002/anie.201203303
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Liu, L. and Zhang, L. (2012), Access to Electron-Rich Arene-Fused Hexahydroquinolizinones through a Gold-Catalysis-Initiated Cascade Process . Angew. Chem. Int. Ed., 51: 7301–7304. doi: 10.1002/anie.201203303
- †
Publication History
- Issue published online: 11 JUL 2012
- Article first published online: 12 JUN 2012
- Manuscript Received: 30 APR 2012
Funded by
- NIGMS. Grant Number: R01 GM084254
- UCSB
Keywords:
- alkaloids;
- cascade reactions;
- catalysis;
- gold;
- indoles
Golden Cascade: With a tethered, electron-rich arene as the internal nucleophile, a gold-catalyzed amide cyclization to an alkyne initiates a cascade process that ends with a Ferrier rearrangement. Electron-rich arene-bearing hexahydroquinolizin-2-ones are formed in good yields and can be converted into indole alkaloids in only a few steps.