Research support from the Hangzhou Normal University (China) is gratefully acknowledged. We thank Dr. Y.-X. Li for the X-ray crystallographic analysis.
Catalytic Asymmetric [4+2] Annulation Initiated by an Aza-Rauhut–Currier Reaction: Facile Entry to Highly Functionalized Tetrahydropyridines†
Article first published online: 2 JUL 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 31, pages 7825–7829, July 27, 2012
How to Cite
Shi, Z., Yu, P., Loh, T.-P. and Zhong, G. (2012), Catalytic Asymmetric [4+2] Annulation Initiated by an Aza-Rauhut–Currier Reaction: Facile Entry to Highly Functionalized Tetrahydropyridines . Angew. Chem. Int. Ed., 51: 7825–7829. doi: 10.1002/anie.201203316
- Issue published online: 25 JUL 2012
- Article first published online: 2 JUL 2012
- Manuscript Received: 30 APR 2012
- Hangzhou Normal University (China)
- asymmetric catalysis;
- synthetic methods
Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.