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Keywords:

  • annulation;
  • asymmetric catalysis;
  • heterocycles;
  • ketones;
  • synthetic methods
Thumbnail image of graphical abstract

Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.