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Keywords:

  • history of science;
  • natural product synthesis;
  • synthetic methods
Thumbnail image of graphical abstract

For almost 200 years, the synthesis of natural products has been practiced. In this time span, not only the target structures have become increasingly more complex (see two examples from the 1970s), the objectives of natural product synthesis have also changed. Likewise, the standards and criteria for the conduction of natural product synthesis have changed. It is these changes that form the subject of this Essay.