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A Molecular Tête-à-Tête Arranged by a Designed Adaptor Protein


  • M.K. thanks the German Science Foundation (DFG) for support within the Emmy Noether Program.


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Come together: The joining of two miniature proteins binding different protein targets in a synthetic adaptor protein is a novel way to induce proximity between proteins. The formation of a ternary complex was shown to cause the phosphorylation of a noninherent substrate (hDM2) by the kinase Hck. The approach holds promise to become a genetically encodable system to redirect enzyme activities in vivo.