Financial support from Spanish Government (CTQ-2009-12168), CAM (“programa AVANCAT CS2009/PPQ-1634”), is acknowledged. J.A. thanks the MICINN for a “Ramón y Cajal” contract.
Asymmetric Synthesis of Cyclobutanes by a Formal [2+2] Cycloaddition Controlled by Dienamine Catalysis†
Article first published online: 22 AUG 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 39, pages 9734–9736, September 24, 2012
How to Cite
Parra, A., Reboredo, S. and Alemán, J. (2012), Asymmetric Synthesis of Cyclobutanes by a Formal [2+2] Cycloaddition Controlled by Dienamine Catalysis . Angew. Chem. Int. Ed., 51: 9734–9736. doi: 10.1002/anie.201203489
- Issue published online: 19 SEP 2012
- Article first published online: 22 AUG 2012
- Manuscript Received: 6 MAY 2012
- Spanish Government. Grant Number: CTQ-2009-12168
- CAM. Grant Number: CS2009/PPQ-1634
- cooperative catalysis;
Trap it: A combination of aminocatalysis with H-bonding activation is used in two new approaches to carry out formal enantioselective organocatalyzed [2+2] cycloaddition reactions. This cooperative catalysis solves the inconveniences associated with this transformation. These two new reactions will open opportunities to find reactivities involving other organocatalytic cycloadditions.