Get access

Asymmetric Synthesis of Cyclobutanes by a Formal [2+2] Cycloaddition Controlled by Dienamine Catalysis

Authors

  • Dr. Alejandro Parra,

    Corresponding author
    1. Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    • Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author
  • Dr. Silvia Reboredo,

    1. Departamento de Química Orgánica, Facultad de Químicas, Universidad Complutense de Madrid (Spain)
    Search for more papers by this author
  • Dr. José Alemán

    Corresponding author
    1. Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    • Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author

  • Financial support from Spanish Government (CTQ-2009-12168), CAM (“programa AVANCAT CS2009/PPQ-1634”), is acknowledged. J.A. thanks the MICINN for a “Ramón y Cajal” contract.

Abstract

original image

Trap it: A combination of aminocatalysis with H-bonding activation is used in two new approaches to carry out formal enantioselective organocatalyzed [2+2] cycloaddition reactions. This cooperative catalysis solves the inconveniences associated with this transformation. These two new reactions will open opportunities to find reactivities involving other organocatalytic cycloadditions.

Get access to the full text of this article

Ancillary