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Umpolung of Fluoroform by C[BOND]F Bond Activation: Direct Difluoromethylation of Lithium Enolates

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Abstract

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Double agent: The direct α-difluoromethylation of lithium enolates using an umpolung form of fluoroform as a difluoromethyl carbocation equivalent leads to an all-carbon quaternary center. Late transition metals are not necessary and the reaction involves activation of inert C[BOND]F bonds with subsequent C[BOND]C bond formation.

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