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Keywords:

  • biaryls;
  • biosynthesis;
  • C[BOND]C coupling;
  • natural products;
  • polyketides
Thumbnail image of graphical abstract

Piecing it together: Aspergillus niger produces kotanin (see structure) by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.