T.L. thanks the PRF-ACS and NSF (CHE 113175) for support, as well as Heather Neu, Dr. Cathy Moore, and Ryan Peterson for their help.
A Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination†
Article first published online: 13 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 42, pages 10580–10583, October 15, 2012
How to Cite
Bloom, S., Pitts, C. R., Miller, D. C., Haselton, N., Holl, M. G., Urheim, E. and Lectka, T. (2012), A Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination . Angew. Chem. Int. Ed., 51: 10580–10583. doi: 10.1002/anie.201203642
- Issue published online: 10 OCT 2012
- Article first published online: 13 SEP 2012
- Manuscript Revised: 20 JUL 2012
- Manuscript Received: 10 MAY 2012
- NSF. Grant Number: CHE 113175
- phase-transfer catalysis;
- synthetic methods
A group effort: Reported is the title reaction using a polycomponent catalytic system involving commercially available Selectfluor, a putative radical precursor N-hydroxyphthalimide, an anionic phase-transfer catalyst (KB(C6F5)4), and a copper(I) bis(imine). The catalyst system formed leads to monofluorinated compounds selectively (see example) without the necessity for an excess of the alkane substrate.