A Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination


  • T.L. thanks the PRF-ACS and NSF (CHE 113175) for support, as well as Heather Neu, Dr. Cathy Moore, and Ryan Peterson for their help.


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A group effort: Reported is the title reaction using a polycomponent catalytic system involving commercially available Selectfluor, a putative radical precursor N-hydroxyphthalimide, an anionic phase-transfer catalyst (KB(C6F5)4), and a copper(I) bis(imine). The catalyst system formed leads to monofluorinated compounds selectively (see example) without the necessity for an excess of the alkane substrate.