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Keywords:

  • apoptosis;
  • glutathione S-transferase omega;
  • inhibitors;
  • peptides;
  • protein modifications
Thumbnail image of graphical abstract

On (cell) suicide watch: The increased permeability of apoptotic cells was used to identify a peptide-based, covalent inhibitor (NJP2) for glutathione S-transferase omega (GSTO1) that is highly selective for apoptotic cells, with no inhibition of healthy cells (see scheme). This apoptosis-specific peptide could also be used for imaging programmed cell death.