Eranthie Weerapana is a Damon Runyon–Rachleff Innovator supported (in part) by the Damon Runyon Cancer Research Foundation (DRR-18-12). We are also grateful for financial support from the Smith Family Foundation and Boston College. We thank Prof. Jianmin Gao, David Alex Shannon, and other members of the Weerapana Lab for comments and critical reading of the manuscript.
An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells†
Article first published online: 6 JUL 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 33, pages 8365–8368, August 13, 2012
How to Cite
Pace, N. J., Pimental, D. R. and Weerapana, E. (2012), An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells . Angew. Chem. Int. Ed., 51: 8365–8368. doi: 10.1002/anie.201203730
- Issue published online: 7 AUG 2012
- Article first published online: 6 JUL 2012
- Manuscript Received: 15 MAY 2012
- Damon Runyon Cancer Research Foundation. Grant Number: DRR-18-12
- Smith Family Foundation
- glutathione S-transferase omega;
- protein modifications
On (cell) suicide watch: The increased permeability of apoptotic cells was used to identify a peptide-based, covalent inhibitor (NJP2) for glutathione S-transferase omega (GSTO1) that is highly selective for apoptotic cells, with no inhibition of healthy cells (see scheme). This apoptosis-specific peptide could also be used for imaging programmed cell death.