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An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells

Authors

  • Nicholas J. Pace,

    1. Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467 (USA)
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  • Daniel R. Pimental,

    1. Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467 (USA)
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  • Prof. Eranthie Weerapana

    Corresponding author
    1. Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467 (USA)
    • Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467 (USA)
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  • Eranthie Weerapana is a Damon Runyon–Rachleff Innovator supported (in part) by the Damon Runyon Cancer Research Foundation (DRR-18-12). We are also grateful for financial support from the Smith Family Foundation and Boston College. We thank Prof. Jianmin Gao, David Alex Shannon, and other members of the Weerapana Lab for comments and critical reading of the manuscript.

Abstract

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On (cell) suicide watch: The increased permeability of apoptotic cells was used to identify a peptide-based, covalent inhibitor (NJP2) for glutathione S-transferase omega (GSTO1) that is highly selective for apoptotic cells, with no inhibition of healthy cells (see scheme). This apoptosis-specific peptide could also be used for imaging programmed cell death.

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