Ceria Nanoparticles that can Protect against Ischemic Stroke

Authors

  • Dr. Chi Kyung Kim,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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    • These authors contributed equally to this work.

  • Taeho Kim,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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    • These authors contributed equally to this work.

  • In-Young Choi,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Min Soh,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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  • Dr. Dohoung Kim,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Young-Ju Kim,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Dr. Hyunduk Jang,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Hye-Sung Yang,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Dr. Jun Yup Kim,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Dr. Hong-Kyun Park,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Dr. Seung Pyo Park,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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  • Sangseung Park,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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  • Dr. Taekyung Yu,

    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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  • Prof. Byung-Woo Yoon,

    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Prof. Seung-Hoon Lee,

    Corresponding author
    1. Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
    • Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)
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  • Prof. Taeghwan Hyeon

    Corresponding author
    1. Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
    • Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)
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  • This work was supported by a grant of the Korean Health Technology R&D Project, Korean Ministry of Health & Welfare (A111014).

Abstract

original image

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

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