These authors contributed equally to this work.
Programmable Magnetic Tweezers and Droplet Microfluidic Device for High-Throughput Nanoliter Multi-Step Assays†
Article first published online: 26 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 43, pages 10765–10769, October 22, 2012
How to Cite
Ali-Cherif, A., Begolo, S., Descroix, S., Viovy, J.-L. and Malaquin, L. (2012), Programmable Magnetic Tweezers and Droplet Microfluidic Device for High-Throughput Nanoliter Multi-Step Assays . Angew. Chem. Int. Ed., 51: 10765–10769. doi: 10.1002/anie.201203862
This work was supported in part by EU project NADINE (FP7-NMP: 246513) and by the Equipex/Idex ANR program for the IPGG project. A.A.-C. acknowledges a PhD fellowship from the French Ministry of Defense; S.B. was supported by a Curie Institute International PhD fellowship.
- Issue published online: 17 OCT 2012
- Article first published online: 26 SEP 2012
- Manuscript Revised: 4 JUL 2012
- Manuscript Received: 18 MAY 2012
- EU. Grant Number: 246513
- magnetic particles;
Tweezing out the answer: A microfluidic device combining droplets (less than 100 nL) and magnetic particles (see scheme) was implemented for fast heterogeneous multiplexed assays. Magnetic tweezers can perform the manipulations required in an immunoassay (capture, extraction, mixing, and rinsing). This method was applied to the diagnosis of congenital hypothyroidism with 14 pM sensitivity.