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Controlling the Chirality of DNA Nanocages


  • This work was supported by the Office of Naval Research and the National Science Foundation of China (No. 81028001). DLS and AFM studies were carried out in the Purdue Laboratory for Chemical Nanotechnology (PLCN). The cryo-EM images were taken in the Purdue Biological Electron Microscopy Facility and the Purdue Rosen Center for Advanced Computing (RCAC) provided the computational resource for the 3D reconstructions.


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Playing DNA Twister: By using asymmetric DNA building blocks, self-assembled DNA nanocages that are chiral on the nanoscale have been designed. The resulting DNA nanocages have been characterized with a variety of methods. Such chiral control could be useful for tuning the photonic/optical properties of DNA-templated nanostructures.