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Keywords:

  • asymmetric catalysis;
  • cycloaddition;
  • enantioselectivity;
  • rhodium;
  • tetrahydropyridazines
Thumbnail image of graphical abstract

A versatile cascade of reactions, triggered by RhII-catalyzed diazo decomposition followed by a vinylogous N[BOND]H insertion/Lewis acid catalyzed Mannich addition, that produces highly substituted 1,2,3,6-tetrahydropyridazines in up to 97 % ee with high yield and diastereocontrol has been developed.