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Keywords:

  • acylation;
  • chemoselectivity;
  • imidazole;
  • indoles;
  • oxazolidinones
Thumbnail image of graphical abstract

Unique reactivity: In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N-acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).