This work was supported by a CAREER award (0643264) from the National Science Foundation (USA) (NSF). S.T.H. and E.E.S. are grateful to the NSF for graduate fellowships.
Chemoselective N-Acylation of Indoles and Oxazolidinones with Carbonylazoles†
Article first published online: 11 JUL 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 33, pages 8304–8308, August 13, 2012
How to Cite
Heller, S. T., Schultz, E. E. and Sarpong, R. (2012), Chemoselective N-Acylation of Indoles and Oxazolidinones with Carbonylazoles . Angew. Chem. Int. Ed., 51: 8304–8308. doi: 10.1002/anie.201203976
- Issue published online: 7 AUG 2012
- Article first published online: 11 JUL 2012
- Manuscript Received: 23 MAY 2012
- National Science Foundation
Unique reactivity: In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N-acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).