Communication

Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo†

  1. Dr. Hong Yan1,
  2. Dr. Cathleen Teh3,
  3. Dr. Sivaramapanicker Sreejith1,
  4. Dr. Liangliang Zhu1,
  5. Anna Kwok1,
  6. Weiqin Fang1,
  7. Xing Ma2,
  8. Kim Truc Nguyen1,
  9. Prof. Dr. Vladimir Korzh3,
  10. Prof. Dr. Yanli Zhao1,2,*

Article first published online: 6 JUL 2012

DOI: 10.1002/anie.201203993

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 33, pages 8373–8377, August 13, 2012

Additional Information

How to Cite

Yan, H., Teh, C., Sreejith, S., Zhu, L., Kwok, A., Fang, W., Ma, X., Nguyen, K. T., Korzh, V. and Zhao, Y. (2012), Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo . Angew. Chem. Int. Ed., 51: 8373–8377. doi: 10.1002/anie.201203993

Author Information

  1. 1

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore (Singapore) http://www.ntu.edu.sg/home/zhaoyanli/

  2. 2

    School of Materials Science and Engineering, Nanyang Technological University (Singapore)

  3. 3

    Laboratory of Fish Development Biology, Institute of Molecular and Cell Biology (Singapore)

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore (Singapore) http://www.ntu.edu.sg/home/zhaoyanli/

  1. †

    We thank the Singapore National Research Foundation Fellowship (NRF2009NRF-RF001-015) and Nanyang Technological University for financial support.

Publication History

  1. Issue published online: 7 AUG 2012
  2. Article first published online: 6 JUL 2012
  3. Manuscript Received: 23 MAY 2012

Funded by

  • Singapore National Research Foundation Fellowship. Grant Number: NRF2009NRF-RF001-015
  • Nanyang Technological University

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (1368K)

Keywords:

  • drug delivery;
  • mesoporous silica nanoparticles;
  • nanoparticles;
  • photothermal switches;
  • zebrafish
Thumbnail image of graphical abstract

Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans–cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.

View Full Article with Supporting Information (HTML) Get PDF (1368K)