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Keywords:

  • drug delivery;
  • mesoporous silica nanoparticles;
  • nanoparticles;
  • photothermal switches;
  • zebrafish
Thumbnail image of graphical abstract

Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon transcis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.