Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo


  • We thank the Singapore National Research Foundation Fellowship (NRF2009NRF-RF001-015) and Nanyang Technological University for financial support.


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Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon transcis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.