Gold–Gold Cooperation in the Addition of Methanol to Alkynes


  • The authors gratefully acknowledge financial support from the Grant agency of the Czech Republic (207/11/0338), the European Research Council (StG ISORI) and the Ministry of Education of the Czech Republic (MSM0021620857). The results from CLIO were obtained thanks to the funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 226716. The CLIO staff, particularly Vincent Steinmetz, are gratefully acknowledged for their help and assistance. We thank Zdeněk Tošner for helping with the NMR spectra acquisition.


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The gold(I)-mediated reaction between an internal alkyne and methanol proceeds by a dual activation mechanism, which directly results in formation of gem-diaurated intermediates. Reaction intermediates were investigated by IR multiphoton dissociation spectroscopy, kinetics by NMR spectroscopy, and the mechanism by DFT calculations.