Enantioselective Rhodium-Catalyzed Nucleophilic Allylation of Cyclic Imines with Allylboron Reagents

Authors


  • We thank the ERC (Starting Grant No. 258580), the EPSRC (Leadership Fellowship to H.W.L.), and the Thai government for support of this work. We thank Dr. Gary S. Nichol (University of Edinburgh) for X-ray crystallography, and the EPSRC National Mass Spectrometry Service Centre at the University of Wales, Swansea, for high-resolution mass spectra. We thank Dr. Uwe Schneider (University of Edinburgh) for helpful discussions.

Abstract

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Chiral allylrhodium nucleophiles: The highly diastereo- and enantioselective title reaction of a range of cyclic imines with various potassium allyltrifluoroborates most likely proceeds via allylrhodium(I) intermediates, and represents the first rhodium-catalyzed enantioselective nucleophilic allylation of π electrophiles with allylboron compounds.

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