The writing's on the (cell) wall: A series of Lipid II analogues with modifications to the peptide moiety were evaluated as substrates of bacterial transglycosylase. The first two positions on the peptide, D-lactate and L-alanine (see scheme), especially their methyl groups, were found to be essential for substrate-binding activity, an important discovery for the design of antibiotics to inhibit cell-wall biosynthesis.
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