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A Smart Nanofiber Web That Captures and Releases Cells

Authors

  • Young-Jin Kim,

    1. Materials and Science Engineering, Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577 (Japan)
    2. Biomaterials Unit, International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
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  • Dr. Mitsuhiro Ebara,

    1. Biomaterials Unit, International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
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  • Prof. Takao Aoyagi

    Corresponding author
    1. Materials and Science Engineering, Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577 (Japan)
    2. Biomaterials Unit, International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
    • Materials and Science Engineering, Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577 (Japan)
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  • We would like to express our gratitude to the Grants-in-Aid for Young Scientists (A) (10013481) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan. We are grateful to Prof. Allan S. Hoffman (University of Washington) and Dr. John M. Hoffman (Stratos Genomics Inc. in USA) for continued and valuable discussion.

Abstract

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Caught in a web: Photo-cross-linkable temperature-responsive polymer-based nanofiber webs have been synthesized that have the ability to capture, encapsulate, and release cells by dynamically transforming the fibrous structure into hydrogel-like structures by wrapping, swelling, and deswelling processes in response to external temperature changes (see picture).

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