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Keywords:

  • biomimetic synthesis;
  • C[BOND]H functionalization;
  • domino reactions;
  • natural products;
  • reduction
Thumbnail image of graphical abstract

Pyrrole reduction: Iterative metal-catalyzed C[BOND]H functionalization reactions facilitated the preparation of a highly substituted pyrrole derivative. This derivative could be transformed into the pyrrole-containing secondary metabolite, rhazinilam, which could in turn be transformed through a reductive transannular cascade process into the structurally complex pyrrolidine-containing alkaloid natural product, aspidospermidine.