L.M. is grateful to the EPSRC and AstraZeneca for a Ph.D. studentship, M.J.G. is grateful for funding from Phillip & Patricia Brown through a Next Generation Fellowship and to unrestricted funding from Novartis. We are grateful to the EPSRC Mass Spectrometry Service at the University of Swansea.
Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products†
Article first published online: 22 AUG 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 37, pages 9288–9291, September 10, 2012
How to Cite
McMurray, L., Beck, E. M. and Gaunt, M. J. (2012), Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products . Angew. Chem. Int. Ed., 51: 9288–9291. doi: 10.1002/anie.201204151
- Issue published online: 5 SEP 2012
- Article first published online: 22 AUG 2012
- Manuscript Received: 28 MAY 2012
- biomimetic synthesis;
- CH functionalization;
- domino reactions;
- natural products;
Pyrrole reduction: Iterative metal-catalyzed CH functionalization reactions facilitated the preparation of a highly substituted pyrrole derivative. This derivative could be transformed into the pyrrole-containing secondary metabolite, rhazinilam, which could in turn be transformed through a reductive transannular cascade process into the structurally complex pyrrolidine-containing alkaloid natural product, aspidospermidine.