From One-Photon to Two-Photon Probes: “Caged” Compounds, Actuators, and Photoswitches

Authors

  • Dr. Guillaume Bort,

    1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)
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  • Dr. Thibault Gallavardin,

    1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)
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  • Dr. David Ogden,

    Corresponding author
    1. Laboratoire de Physiologie Cérébrale, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)
    • David Ogden, Laboratoire de Physiologie Cérébrale, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)

      Peter I. Dalko, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)

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  • Dr. Peter I. Dalko

    Corresponding author
    1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)
    • David Ogden, Laboratoire de Physiologie Cérébrale, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)

      Peter I. Dalko, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris (France)

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Abstract

Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two-photon excitation has significant advantages deep in biological tissues, but raises problems in the design of “smart” probes compatible with cell physiology. This Review discusses the chemical challenges in generating suitable two-photon probes.

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