Relay Catalysis Enables Hydrogen Gas to Participate in Asymmetric Organocatalytic Hydrogenation

Authors

  • Dr. Feng Shi,

    1. School of Chemistry & Chemical Engineering, Jiangsu Normal University (China)
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  • Prof. Liu-Zhu Gong

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China)
    • Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China)
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Abstract

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Teamwork: Through relay catalysis by a RuII complex and a chiral phosphoric acid ((S)-BPA in the scheme) recently developed by Zhou's group, hydrogen gas can act as the terminal reductant in the catalytic asymmetric hydrogenation of heterocycles. This is a completely new concept in the area of asymmetric hydrogenation.

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