Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues


  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie.


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Remote control: The formation of aspartimides is greatly decreased during peptide elongation and during convergent sugar couplings of Asp-X-Ser/Thr peptides that contain a pseudoproline (red; see scheme). The robust approach efficiently joins complex peptides and N-glycans on the solid phase thus facilitating the availability of glycopeptides and glycoproteins.