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Keywords:

  • DNA nanotechnology;
  • fluorescent probes;
  • immunochemistry;
  • nucleic acids;
  • strand displacement
Thumbnail image of graphical abstract

DNA-based erasers: The designed strand-displacement reactions between dynamic DNA probes (carrying fluorescent dyes (★) and quencher domains (•)) and DNA–antibody conjugates generate detachable immunofluoresence-reporting complexes that can be assembled (first image) and disassembled (second image) reversibly within fixed cells. With this system, different protein targets can be imaged sequentially within the same cells (third image).