Financial support by ETH Zurich is kindly acknowledged.
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/olbannercenter.gif?v=1&s=c083e1920cd41ed129901c116018eab93b5ad3c4)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Incorporation of Penicillin-Producing Fungi into Living Materials to Provide Chemically Active and Antibiotic-Releasing Surfaces†
Article first published online: 9 OCT 2012
DOI: 10.1002/anie.201204337
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 51, Issue 45, pages 11293–11296, November 5, 2012
Additional Information
How to Cite
Gerber, L. C., Koehler, F. M., Grass, R. N. and Stark, W. J. (2012), Incorporation of Penicillin-Producing Fungi into Living Materials to Provide Chemically Active and Antibiotic-Releasing Surfaces . Angew. Chem. Int. Ed., 51: 11293–11296. doi: 10.1002/anie.201204337
- †
Publication History
- Issue published online: 30 OCT 2012
- Article first published online: 9 OCT 2012
- Manuscript Revised: 12 SEP 2012
- Manuscript Received: 4 JUN 2012
Funded by
- ETH Zurich
Keywords:
- antibiotics;
- bacteria;
- bioinspired materials;
- biomimetic synthesis;
- penicillin
Living materials: Artificial biological niches are loaded with the penicillin-producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on-site. No reloading of the active compound is needed. Gram-positive bacteria were efficiently killed if nearby, whereas Gram-negative bacteria (control experiment, not sensitive to penicillin) were not affected.