SEARCH

SEARCH BY CITATION

Keywords:

  • C[BOND]C coupling;
  • copper;
  • heterocycles;
  • oxygen;
  • synthetic methods
Thumbnail image of graphical abstract

O2 leading the way: The title reaction proceeds through an oxidation/cyclization sequence, thus representing the first copper-catalyzed coupling reaction of hydrazones through a Cmath image[BOND]H bond functionalization process (see scheme; DMF=N,N′-dimethylformamide, Py=pyridine). The method provides an environmentally friendly and atom-efficient approach to biologically active cinnoline derivatives.