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Metal Carbonyl–Gold Nanoparticle Conjugates for Live-Cell SERS Imaging

Authors

  • Dr. Kien Voon Kong,

    1. Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), 138667 Singapore (Singapore)
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  • Zhiyong Lam,

    1. Division of Chemistry & Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Wenda Douglas Goh,

    1. Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), 138667 Singapore (Singapore)
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  • Prof. Weng Kee Leong,

    Corresponding author
    1. Division of Chemistry & Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
    • Division of Chemistry & Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Prof. Malini Olivo

    Corresponding author
    1. Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), 138667 Singapore (Singapore)
    2. School of Physics, National University of Ireland, Galway (Ireland)
    3. Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Singapore)
    • Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), 138667 Singapore (Singapore)
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  • We acknowledge helpful discussions with Dr. U. S. Dinish and technical assistance from Tianxun Gong. We also thank Ethan Chong Jin Ong from Nanyang Technological University, Singapore, for his assistance in the preparation of OM-NP(PEG)-L conjugates and measurement. This work was supported by the SBIC (Biomedical Research Council, Agency for Science, Technology, and Reseach, Singapore).

Abstract

original image

Conjugates of organometallic osmium carbonyl clusters and gold nanoparticles (see picture) show a strong carbonyl signal in surface-enhanced Raman spectroscopy. The ease of bio-functionalization and the high stability and good dispersibility in aqueous solution make these conjugates excellent candidates for biomedical applications, as demonstrated by live-cell imaging with the carbonyl signals of OM-NP(PEG)-L conjugates.

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