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Keywords:

  • hydrogenation;
  • hyperpolarization;
  • NMR spectroscopy;
  • parahydrogen;
  • peptides
Thumbnail image of graphical abstract

Site-specific spin polarization labeling of a peptide was conducted by homogeneous hydrogenation with parahydrogen. Surprisingly, polarization transfer to a remote alanine residue was observed. The diastereoselectivity of the hydrogenation reaction was determined, and these results show that parahydrogen can be used to enhance signals and elucidate the hydrogenation processes of dehydropeptide units in complex molecules.