Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water


  • We thank the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) for generous support and promotion of this work within the collaborative research centre SFB583 “Redox-Active Metal Complexes” (Sonderforschungsbereich SFB583 “Redoxaktive Metallkomplexe”). E.B. thanks the Graduate School of Molecular Science at the University of Erlangen-Nürnberg for the support of her research work.


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It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP+ (and a little 2-propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).