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Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal–Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts


  • Funding was provided by the U.S. Department of Energy (DOE DE-SC0001015 and DE-AR0000073). Special thanks to Dr. P. Wu from Sichuan University, China for his help on enzyme kinetic studies.


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Biomimetic MOF: Extremely stable MOFs with different open metal sites and ultra-large 1D channels, PCN-222 (Fe, Mn, Co, Ni, Cu, and Zn), have been assembled with eight-connected Zr6 clusters and redox-active metalloporphyrin motifs. PCN-222(Fe) shows peroxidase-like activity in aqueous solution, exhibiting highly effective biomimetic oxidation on a number of substrates.