Homochiral Crystallization of Metal–Organic Silver Frameworks: Asymmetric [3+2] Cycloaddition of an Azomethine Ylide


  • We gratefully acknowledge financial support from the NSFC (21171029 and 21025102).


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Enantiomeric silver-based MOFs were obtained through a homochiral crystallization of cinchonine and cinchonidine enantiomers as chiral adducts with silver. These MOFs exhibited excellent catalytic activity for asymmetric [3+2] cycloaddition (see scheme), giving products with high enantioselectivity.