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A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells


  • We acknowledge financial support from the Skaggs Institute for Chemical Biology (to P.G.S). We thank Dr. Shoutian Zhu and Dr. Kristen Johnson for helpful discussion and critical reading of the manuscript.


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Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial-fragmentation-associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture).