Get access
Advertisement

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

Authors


  • We acknowledge financial support from the Skaggs Institute for Chemical Biology (to P.G.S). We thank Dr. Shoutian Zhu and Dr. Kristen Johnson for helpful discussion and critical reading of the manuscript.

Abstract

original image

Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial-fragmentation-associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture).

Get access to the full text of this article

Ancillary