1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/olbannercenter.gif?v=1&s=c083e1920cd41ed129901c116018eab93b5ad3c4)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Cover Picture
Back Cover: Bioinspired Total Synthesis of Agelastatin A (Angew. Chem. Int. Ed. 28/2012)
Article first published online: 28 JUN 2012
DOI: 10.1002/anie.201204757
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Reyes, J. C. P. and Romo, D. (2012), Back Cover: Bioinspired Total Synthesis of Agelastatin A (Angew. Chem. Int. Ed. 28/2012). Angew. Chem. Int. Ed., 51: 7050. doi: 10.1002/anie.201204757
Publication History
- Issue published online: 4 JUL 2012
- Article first published online: 28 JUN 2012
Keywords:
- alkaloids;
- biomimetic synthesis;
- N-acyliminium;
- Nazarov cyclization;
- pyrrole-2-amino imidazole alkaloids
Enzymatic Transformations can sometimes be emulated in the laboratory using judiciously chosen reagents and reaction conditions. In their Communication on page 6870 ff., J. C. P. Reyes and D. Romo describe a bioinspired synthetic route to agelastatin A, a unique tetracyclic member of the pyrrole-2-aminoimidazole family of alkaloids. The efficiency of the developed route, in which the formation of the C-ring of the natural product precedes that of the B-ring, suggests biosynthetic relevance.