This work was made possible by grants from Aarhus University, OChemSchool, Carlsberg Foundation, and FNU. F.C.A. thanks CSIC for predoctoral JAE grant. We thank Dr. Jacob Overgaard for performing X-ray analysis.
Enantioselective H-Bond-Directing Approach for Trienamine-mediated Reactions in Asymmetric Synthesis†
Article first published online: 9 AUG 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 36, pages 9088–9092, September 3, 2012
How to Cite
Albrecht, Ł., Cruz Acosta, F., Fraile, A., Albrecht, A., Christensen, J. and Jørgensen, K. A. (2012), Enantioselective H-Bond-Directing Approach for Trienamine-mediated Reactions in Asymmetric Synthesis . Angew. Chem. Int. Ed., 51: 9088–9092. doi: 10.1002/anie.201204790
- Issue published online: 28 AUG 2012
- Article first published online: 9 AUG 2012
- Manuscript Received: 19 JUN 2012
- Aarhus University
- Carlsberg Foundation
- asymmetric synthesis;
- synthetic methods;
Right direction: The presented enantioselective strategy for the preparation of diversely functionalized tetrahydroxanthones is based on a trienamine-mediated cycloaddition between 2,4-dieneals and activated chromones. It is possibile to control the stereochemical outcome of such reactions by employing an H-bond-directing aminocatalyst.