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Enantioselective H-Bond-Directing Approach for Trienamine-mediated Reactions in Asymmetric Synthesis


  • This work was made possible by grants from Aarhus University, OChemSchool, Carlsberg Foundation, and FNU. F.C.A. thanks CSIC for predoctoral JAE grant. We thank Dr. Jacob Overgaard for performing X-ray analysis.


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Right direction: The presented enantioselective strategy for the preparation of diversely functionalized tetrahydroxanthones is based on a trienamine-mediated cycloaddition between 2,4-dieneals and activated chromones. It is possibile to control the stereochemical outcome of such reactions by employing an H-bond-directing aminocatalyst.