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Cover Picture
Back Cover: Template-Directed Synthesis in 3′- and 5′-Direction with Reversible Termination (Angew. Chem. Int. Ed. 33/2012)
Article first published online: 12 JUL 2012
DOI: 10.1002/anie.201204827
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Kaiser, A., Spies, S., Lommel, T. and Richert, C. (2012), Back Cover: Template-Directed Synthesis in 3′- and 5′-Direction with Reversible Termination (Angew. Chem. Int. Ed. 33/2012). Angew. Chem. Int. Ed., 51: 8394. doi: 10.1002/anie.201204827
Publication History
- Issue published online: 7 AUG 2012
- Article first published online: 12 JUL 2012
Keywords:
- DNA;
- solid-phase synthesis;
- primer extension;
- protecting groups;
- reversible terminator
Simultaneous chemical primer extension in both 3′- and 5′-direction is reported by C. Richert et al. in their Communication on page 8299 ff. The use of magnetic beads as a solid support and azidomethyloxycarbonyl moieties as protecting groups provided control over the extension steps directed by a DNA sequence. The method combines features of replication and of automated DNA synthesis.